Quick details:
Pioglitazone Hydrochloride
ACTOS;PIOGLITAZONE HYDROCHLORIDE
Product Name:[5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-] thiazolidinedione hydrochloride
Synonyms:5-((4-(2-(5-ETHYL-2-PYRIDINYL)ETHOXY)PHENYL)METHYL)-2,4-THIAZOLIDINEDIONE, HCL;[5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-] thiazolidinedione hydrochloride;ACTOS;PIOGLITAZONE HCL;PIOGLITAZONE HYDROCHLORIDE;U-72107A;Pioditazone hydrochloride;5-[4-[2-(N-Methyl-N-(2-pyridyl)amino)ethoxy]benzylidine]-2,4-thiazolidinedionehydrochloride
Pioglitazone Hydrochloride CAS:112529-15-4
Pioglitazone Hydrochloride MF:C19H21ClN2O3S
In addition, Actos ( pioglitazone), a drug used to treat diabetes, also improved manyfeatures of NASH but was associated with weight gain
Pioglitazone Hydrochloride Description
Pioglitazone Hydrochloride is the hydrochloride salt preparation of Pioglitazone, a specific ligand of PPAR-γ (peroxisome proliferator-activated receptor-γ). Pioglitazone is a thiazolidinedione compound described to produce antiinflammatory and antiarteriosclerotic effects. Pioglitazone is demonstrated to prevent L-NAME-induced coronary inflammation and arteriosclerosis and to suppress increased TNF-α mRNA produced by aspirin-induced gastric mucosal injury. Pioglitazone Hydrochloride is an activator of PPAR γ.
COA
|
TESTS |
SPECIFICATIONS |
RESULTS |
|
Description |
White to off-white powder |
White powder |
|
Identification |
IR/ HPLC |
Complies |
|
Residue On Ignition |
NMT 0.2% |
0.05% |
|
Heavy Metals |
NMT 20ppm |
LESS THAN 10ppm |
|
Loss On Drying |
NMT 0.5% |
0.32% |
Related Substances
(By HPLC)
Single Impurity
Total Impurity |
NMT 0.5%
NMT 1.0% |
0.06%
0.2% |
|
Assay (By HPLC) |
98.0-102.0% |
99.8% |
Usage:
Pioglitazone is a prescription drug of the class thiazolidinedione (TZD) with hypoglycemic (antihyperglycemic, antidiabetic) action to treat diabetes. It is used to improve glucose control in adults over the age of 18 with type 2 diabetes.
China (Mainland)