1. Quick Detail:
Colistin sulfate
Synonyms: belcomycin;colimycinsulfate;colistinsulfat;colomycinsyrup;polymyxinesulfate(salt);COLISTIN SULFATE;COLISTIN SULFATE SALT;COLISTIN SULPHATE
CAS: 1264-72-8
MF: 2(C52H98N16O13).5(H2SO4)
MW: 2801.27
EINECS: 215-034-3
Chemical Properties Powder
Usage Cyclic polypeptide antibiotic produced by Bacillus polymyxa. Complex mixture of at least 30 components, primarily colistins A and B. [α]D= -65° (c= 1, Water) LOD: 3% DAB= α,γ-diaminobutyric acid Heavy Metals: 20ppm Colistin A R= (+)-6-methyloctanoyl Arsenic Content: 2ppm/g Colistin B R= 6-methylheptanoyl Sulfate: 16-18% Biological Potency (dry basis): 19600U/mg
Usage antibacterial
Usage neuromuscular blocker
Usage Cyclic polypeptide antibiotic produced by Bacillus polymyxa. Complex mixture of at least 30 components, primarily colistins A and B. [a]D= -65 (c= 1, Water) LOD: 3%
2. Description:
Colistin sulphate (col-iss-tin sul-fate) is a medicine which is used in certain types of bacterial infections.
The information in this Medicine Guide for Colistin sulphate varies according to the condition being treated and the particular preparation used.
3. Specification:
Test |
Specification |
|
Characteristics |
White or almost white powder |
|
Identification |
Meets EP specification |
|
PH |
4.0 ~ 6.0 |
|
Loss on drying |
≤3.5% |
|
Optical rotation |
-63° ~ -73° |
|
Sulphated ash |
≤1.0% |
|
Sulphate (dried basis) |
16.0% ~ 18.0% |
|
Content (Dry basis HPLC) |
Colistin E1-I≤10% |
|
|
Colistin E1-7MOA≤10% |
|
|
Colistin E3≤10% |
|
|
E1+ E2+E3+E1-I+E1-7MOA≥77.0% |
|
Related substances |
Any impurity≤4.0% |
|
|
Total impurity≤23.0% |
|
Potency(Moisture basis |
------ |
|
Potency (Dried basis |
≥19000IU/mg
|
4. Applications:
This medication is used to treat certain stomach, bowel and digestive tract infections.
China (Mainland)