99% Purity Mupirocin Pharmaceutical Steroid CAS 12650-69-0
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Mupirocin
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Synonyms |
MUPIROCIN;MUPIROCIN CALCIUM;PSEUDOMONIC ACID;PSEUDOMONIC ACID A;(2s-(2-alpha(e;4-beta,5-alpha(2r*,3r*(1r*,2r*))))-3-beta;bactroban;nonanoicacid,9((3-methyl-1-oxo-4-(tetrahydro-3,4-dihydroxy-5-((3-(2-hydroxy-1 |
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CAS |
12650-69-0 |
|
MF |
C26H44O9 |
|
MW |
500.62 |
|
EINECS |
EINECS: 231-791-2 |
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purity |
99% |
|
appearance |
White Crystalline Solid |
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Categories |
Intermediates&FineChemicals;Pharmaceuticals; |
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Description of Mupirocin
1. Mupirocin which is a new type of local topical antibiotic and a kind of metabolic substance produced in the culture solution of pseudomonas fluorescence, that is, Pseudomonas A. Mainly through reversibly combined with isoleucine transfer RNA synthetase, this product can prevent the isoleucine incorporation and terminate the protein synthesis in cells containing isoleucine, leading to bacterial death. At low concentrations, this product has the inhibitory effect and at high concentrations, it has the bactericidal effect.
2.This product is highly sensitive to a variety of gram-positive bacteria associated with skin infections, particularly staphylococcus aureus (including drug-resistant staphylococcus aureus) and streptococcus pyogenes; and it is also available for listeria monocytogenes and erythema erysipelothrix bacteria; it is generally not sensitive to gram-negative bacteria, but have some antibacterial effect on some Gram-negative bacteria such as E. coli, neisseria, haemophilus influenzae and Neisseria gonorrhoeae and is not sensitive to the majority of anaerobic bacteria and the normal flora of the skin and has low efficacy against fungi. Rate of occurrence is very low in vitro resistant mutants. After applied into the skin, this medicine can penetrate into the stratum corneum, but the absorption rate is very low. The binding rate of this drug and human serum protein is 95%. when absorbed, it is rapidly metabolized to an inactive substance single spore acid (Monic Acid) and excreted by the kidneys.
3.Currently, in China, mupirocin is mainly and clinically used for the treatment of staphylococcus aureus and streptococcus caused by various infectious skin diseases: primary skin infections such as impetigo, folliculitis, and boils carbuncles etc; secondary skin infections such as eczema, atopic dermatitis, skin ulcers, surgical wounds, small burns, skin trauma; and other prevent infections such as small wounds, wound infections, and other sterilization venereal damage.
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COA
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Items of analysis |
Specification |
Results |
Appearance
Cerstallinity |
A White or off-white powder
Conforms |
Off-white micro powder
Conforms |
Identification
pH |
Positive
3.5-4.5 |
Conforms
3.67 |
Water
Residual solvents |
Not more than 1.0%
|
0.16%
|
Heptane |
Not more than 5000ppm
Not more than 5000ppm |
Conforms
Conforms |
Acetone
Assay |
Not more than 5000ppm
Not less than 920ug/mg and not more than 1020ug/mg |
Conforms |
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Application of Mupirocin
1. antibacterial, antimycoplasmal, isoleucyl-tRNA synthetase inhibitor
2. Mupirocin, is a major component of the pseudomonic acid, an antibiotic complex produced by Pseudomonas fluorescens NCIB 10586. Topical antibacterial.
3. Pseudomonic acid is a potent antibiotic produced by Pseudomonas fluorescens, reported by Fuller et al. in 1971. Pseudomonic acid has broad spectrum activity against Gram positive bacteria and was approved for topical human use in 1985. Pseudomonic acid acts as a potent and selective inhibitor of isoleucyl-tRNA synthetase.
4. vasodilator
5. An antibiotic inhibitor of isoleucyl-tRNA synthetase
China (Mainland)