Quick detail
Name: Neomycin Sulphate
CAS No.: 1405-10-3
Formula: C23H48N6O17S
Molecular Weight: 712.7222
EINECS: 215-773-1
Boiling Point: 1046.1° C at 760 mmHg
Flash Point: 586.5° C
Purity: 99%
Appearance: White or yellowish-white powder
Usage: As a broad-spectrum antibiotic, against Staphylococcus aureus, diphtheria and anthrax role

Indications and Usage for Neomycin Sulfate
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Neomycin Sulfate tablets and other antibacterial drugs, Neomycin Sulfate tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Suppression of Intestinal Bacteria
Neomycin Sulfate tablets are indicated as adjunctive therapy as part of a regimen for the suppression of the normal bacterial flora of the bowel, e.g., preoperative preparation of the bowel. It is given concomitantly with erythromycin enteric-coated base 

Hepatic Coma (Portal-Systemic Encephalopathy)
Neomycin Sulfate has been shown to be effective adjunctive therapy in hepatic coma by reduction of the ammonia-forming bacteria in the intestinal tract. The subsequent reduction in blood ammonia has resulted in neurologic improvement.

Contraindications
Neomycin Sulfate oral preparations are contraindicated in the presence of intestinal obstruction and in individuals with a history of hypersensitivity to the drug.

Patients with a history of hypersensitivity or serious toxic reaction to other aminoglycosides may have a cross-sensitivity to neomycin. Neomycin Sulfate oral preparations are contraindicated in patients with inflammatory or ulcerative gastrointestinal disease because of the potential for enhanced gastrointestinal absorption of neomycin.