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Details
Chemical information
Product Name: Flunarizine Hydrochloride
Model No.: ANT-652
Appearance:White Solid
Suitable People:ALl
CAS No.:30484-77-6
Molecular Formula: C26H28Cl2F2N2
Molecular Weight: 477.42
Melting Point:188-190 C
Product Specifications: Pharmaceutical Grade
Purity: 99%+
Standard:Qualified
MOQ(Minimum Order Quantity): 10g
Payment: L/C, T/T,
Shipment:EMS, DHL, FedEx, TNT
Packing: Foil Bag or as Require
Applications/Usage
Calcium channel blocker; fluorinated derivative of Cinnarizine. Vasodilator (cerebral and peripheral). This is the labeled analog.
Effects
These agents are calcium-ion influx inhibitors (slow-channel blocking agents). Although their mechanism is not completely understood, they are thought to inhibit calcium ion entry through select voltage-sensitive areas termed "slow channels" across cell membranes. By reducing intracellular calcium concentration in cardiac and vascular smooth muscle cells, they dilate coronary arteries and peripheral arteries and arterioles, and may reduce heart rate, decrease myocardial contractility (negative inotropic effect), and slow atrioventricular (AV) nodal conduction. Serum calcium concentrations are unchanged, although there is some evidence that elevated serum calcium concentrations may alter the therapeutic effect of verapamil
Formulations
Dosage
The results of several meta-analyses of clinical trials in post-myocardial infarction patients and patients with angina and of observational studies in hypertensive patients have suggested that taking short-acting nifedipine may increase the risk of adverse cardiovascular events and/or mortality, especially when given in high doses. Consequently, the National Heart, Lung, and Blood Institute (NHLBI) recommends that short-acting nifedipine be used with extreme caution in the treatment of hypertension or angina, especially when given in higher doses. Other drugs, such as beta-adrenergic blocking agents and diuretics, have been found to reduce the risk of major cardiovascular events and mortality in the treatment of hypertension and are recommended as preferred treatment by The Fifth Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure.
Amlodipine will not protect against the consequences of abrupt beta-blocker withdrawal; gradual beta-blocker dose reduction is recommended
For oral dosage forms only
Oral dosage must be titrated for each patient as needed and tolerated.
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