Flubendazole with CAS No. 31430-15-6 in Hot Sale
Description
Flubendazole
1. CAS. 31430-15-6
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3. Best quality and most competitive price
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Characteristics and applications
Flubendazole is a synthetic benzimidazole de-worming drugs, can inhibit the absorption of cells of the worm microtubule polymerization.
Flubendazole is a broad-spectrum anthelmintic, effective in treatment of dogs in vivo parasites, such as gastrointestinal roundworm, hookworm, whipworm; But also pigs and poultry, the body can be treated in many gastrointestinal parasites, such as large Pig roundworm (Ascaris suum), stomach red pig round worm (Hyostrongylus rubidus), there are Oesophagostomum (Oesophagostomum dentatum), pig whipworm (Trichuris suis), lung, after a round worm (Metastrongylus apri) and so on. Flubendazole can not only kill the adult, it can also kill eggs.
Storage / transportion
Keep container tightly closed in a cool, well-ventilated area.
Usage
Flubendazole is a synthetic anthelmintic belonging to the benzimidazole carbamates which acts by inhibiting the microtubular assembly in absorptive cells of nematodes. It acts by binding to tubulin, the dimeric subunit protein of the microtubules. It inhibits microtubular assembly in absorptive cells: i. e. Of intestinal cells of nematodes. This is shown by disappearance of cytoplasmic microtubules, accumulation of secretory granules in the cytoplasm due to a block in their transport, leading to an impaired coating of the cellular membrane and a decreased digestion and absorption of nutrients. Irreversible lytic degeneration of the cell, due to the accumulation of secretory substances (hydrolytic and proteolytic enzymes), results in the death of the parasite.
Package
20kg/drum
ITEM |
SPECIFICATIONS |
RESULT |
Description |
|
Appearance |
White or almost white powders |
Almost white powders |
|
Identification (IR) |
Complies with spectrum of flubendazol CRS |
Complies |
Related Substances |
|
Total Impurities |
≤1.5% |
1.3% |
Individual Specified |
|
Impurity A |
≤0.25% |
0.13% |
|
Impurity B |
≤0.25% |
0.07% |
|
Impurity C |
≤0.25% |
0.06% |
|
Impurity D |
≤0.25% |
0.09% |
|
Impurity E |
≤0.25% |
0.18% |
|
Impurity F |
≤0.5% |
0.24% |
|
Impurity G |
≤0.25% |
0.24% |
|
Any other impurity with a relative retention between 1.2 and 1.3 |
≤0.25% |
0.08% (RRT:0.24)
0.07% (RRT:0.24)
0.05% (RRT:1.28)
0.05% (RRT:1.30) |
|
Any Other Impurity |
≤0.10% |
0.05% (RRT:1.33) |
|
Loss on Drying |
≤0.5% |
0.30% |
|
Sulphated Ash |
≤0.1% |
0.03% |
Residual solvent |
|
Methanol |
≤3000ppm |
541PPM |
|
Benzene |
≤2ppm |
2PPM |
|
Assay |
99.0%~101.0% calculated on the dry basis |
99.8% |
|
Assay of Polymorphic b (IR) |
≥90.0% |
98.0% |
CONCLUSION :The items tested meet the requirement of EUROPEAN PHARMACOPOEIA 7.0 |
China (Mainland)