Anti-Allergic Drug Raw Cetirizine Hcl 83881-52-1
Quick Details:
Product Name: Cetirizine hydrochloride
Synonyms: (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)aceticaciddihydro;(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-aceticacidihyd;ucb-p071;ZYRTEC;2-(2-{4-[(4-chlorophenyl)(phenyl)-methyl]piperazino}ethoxy)acetic acid dihydrochloride;AKOS 92015;CETIRIZIN DIHYDROCHLORIDE;CETIRIZINE 2HCL
CAS: 83881-52-1
MF: C21H26Cl2N2O3
MW: 425.35
EINECS: 222-225-5
Product Categories: Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Histamine receptor;Aromatics;Heterocycles;Metabolites & Impurities;API;Aromatics, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;DOPRAM
COA:
|
Item of Analysis |
Specification |
Results |
|
Appearance |
A white or almost white crystalline |
A white powder |
|
Standard |
USP Cetirizine Hydrochloride RS USP |
Comforming |
|
Residue on ignition |
≤0.2% |
0.03% |
|
Heavy Metal |
≤10ppm |
6ppm |
|
total impurity |
≤0.3% |
0.12% |
|
acidity |
1.2-1.8% |
1.5 |
|
Loss on drying |
≤0.5% |
0.28% |
|
Purity |
98.0%102.0% |
99.45% |
|
Conclusion |
Qualified |
|
Medical uses:
Allergies:
Cetirizine's primary indication is for hay fever and other allergies. Because the symptoms of itching and redness in these conditions are caused by histamine acting on the H1 receptor, blocking those receptors temporarily relieves those symptoms.
Cetirizine is also commonly prescribed to treat acute and (in particular cases) chronic urticaria, more efficiently than any other second-generation antihistamine.
Rhinovirus infection:
Interleukin 6 and interleukin 8 have been shown to be elevated in acute respiratory distress syndrome.[2]Cetirizine contains L- and D-stereoisomers. Chemically, levocetirizine is the active L-enantiomer of cetirizine. One recent study of airway epithelial cells showed that levocetirizine may have beneficial effects on the pathophysiologic changes related to human rhinovirus (HRV) infection.
China (Mainland)