Granisetron hydrochloride

1.Basic information:

Product Name:    Granisetron hydrochloride
Synonyms:    1-methyl-n-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-1h-indazole-3-carboxamid;endo-1-methyl-n-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-1h-indazole-3-carboxa;endo-monohydrochlorid;midehydrochloride;1-METHYL-N-[(3-ENDO)-9-METHYL-9-AZABICYCLO[3.3.1]NON-3-YL]-1H-INDAZOLE-3-CARBOXAMIDE HYDROCHLORIDE;KYTRIL;BRL-43694A;GRANISERTROL HYDROCHLORIDE
CAS:    107007-99-8
MF:    C18H25ClN4O
MW:    348.87    
Product Categories:    Pharmaceutical material and intermeidates;Active Pharmaceutical Ingredients;API;Heterocyclic Compounds;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;Granisetron;Serotonin receptor;Serotonin;Heterocycles;SINTROM;Other APIs;Digestive System
Mol File:    107007-99-8.mol

2.Chemical Properties:

MP     290-292°C
storage temp.     Room temp
CAS DataBase Reference    107007-99-8

3.Safety Information:

Hazard Codes     Xn,Xi
Risk Statements     22-62-37/38-36/37/38-36
Safety Statements     26-36-37
RTECS     NK7882200

4.Usage And Synthesis:

Usage    A specific serotonin (5HT3) receptor antagonist. Used as an antiemetic. Granisetron HCl is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemothera py. Its main effect is to reduce the activity of the vagus nerve. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarini c receptor