Product Description

1.Base Date of Pimecrolimus

 Name:Pimecrolimus

 Purity:99%

 Molecular formular:C43H68ClNO11

 

2. Details of Pimecrolimus

Superlist Name:Pimecrolimus

Molecular Formula:C43H68ClNO11

CAS No.:137071-32-0 

Purity:99%

Synonyms:SDZ-ASM 981; Elidel

Molecular Weight:810.45

Appearance:white powder

Application:Pharmaceutical Intermediates

 

4.Description of Pimecrolimus

 

Pimecrolimus is a natural ascomycin macrolactam that binds to macrophilin-12 (FKBP-12) and inhibits calcineurin as well as prolyl isomerase (rotamase).Presumably through these Pimecrolimus is a natural ascomycin macrolactam that binds to macrophilin-12 (FKBP-12) and inhibits calcineurin as well as prolyl isomerase (rotamase).Presumably through these actions, it blocks the activation of T cells by allogeneic dendritic cells (IC50 = 0.55 nM) without affecting dendritic cells.Moreover, pimecrolimus suppresses the generation of pro-inflammatory cytokines by T cells, the release of pre-formed inflammatory mediators from mast cells, and the activation of eosinophils.These eactions, it blocks the activation of T cells by allogeneic dendritic cells (IC50 = 0.55 nM) without affecting dendritic cells.Moreover, pimecrolimus suppresses the generation of pro-inflammatory cytokines by T cells, the release of pre-formed inflammatory mediators from mast cells, and the activation of eosinophils.These effects support the use of pimecrolimus in countering inflammatory skin diseases, such as atopic dermatitis (eczema) and psoriasis