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CAS NO.149506-35-4
A(1-2)Kilogram
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Product Name: Dapagliflozin
Cas No: 149506-35-4
Molecular Formula: C21H25ClO6
Appearance: white powder
Application: Research purpose
Delivery Time: within 1-3 working day
Package: 1kg/Aluminum foil bag
Production Capacity: 500 Kilogram/Month
Purity: 98.5%Storage: Kept in a cool, dry and ventilated place
.Transportation: by air
Min order: 1 Gram
Dapagliflozin , the trade name is Farxiga in the U.S. and Forxiga in the EU and Russia. It is a drug of the gliflozin class, used to treat type 2 diabetes. It was developed by Bristol-Myers Squibb in partnership with AstraZeneca.
Mechanism of action
Dapagliflozin inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2) which are responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter mechanism causes blood glucose to be eliminated through the urine.In clinical trials, dapagliflozin lowered HbA1c by 0.6 versus placebo percentage points when added to metformin.
Selectivity
The IC50 for SGLT2 is less than one thousandth of the IC50 for SGLT1 (1.1 versus 1390 nmol/L), so that the drug does not interfere with intestinal glucose absorption.
Research
Clinical trials to assess effectiveness for patients with type 1 diabetes are underway.
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