Galanthamine Hydrobromide
Product Specification: 98% 99% Galanthamine Hydrobromide
Latin Name: Lycoris radiata (L.herit.)
Product Type: White to off-white crystalline powder
Part of the Plant Used: Tuber (Fresh, 100% Natural)
Extract Method: Hydro-alcoholic extraction
CAS#: [1953-04-4]
Molecular formula:C17H21NO3.HBr;C17H22BrNO3
Molecular Weight: 287.36
Test Item: Appearance, Identification, Residue on Ignition, Specific Rotation, Loss on drying, pH, Solvent Residual, Assay, Ralated Substances
Description:
Galanthamine is an effective,competitive and reversible acetylcholine esterase inhibitor,especially used in curing lightly and moderate Alzheimer's Disease.
Function:
Galanthamine Hydrobromide is the anti-cholinesterase, weak effect. It has strong effect to the central nervous system through the blood brain barrier. It mainly cures the infantile paralysis sequelae, sweeny and myasthenia gravis pseudoparalytica, etc. It also can be applied to puerilism, posttraumatic apoplexy, polyneuritis and radiculitis.
Clinic function: mainly used in myasthenia gravis, poliovirus quiescent stage and sequela, also in polyneuritis, funiculitis and sensorimotor barrier caused by nervous system disease or traumatism. It's major used in Alzheimer's disease, has the principal function for dement and dysmnesia caused by organic brain damage.
Application
Galanthamine Hydrobromide mainly used in myasthenia gravis, poliovirus quiescent stage and sequela, also in polyneuritis, funiculitis and sensorimotor barrier caused by nervous system disease or traumatism. It's major used in Alzheimer's disease, has the principal function for dement and dysmnesia caused by organic brain damage.
COA
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Items |
Specifications |
Results |
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Characters |
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Appearance |
White or almost white crystalline powder |
White crystalline powder |
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Solubility Test |
Soluble in 0.1 N NaOH, sparingly soluble in water, very slightly soluble in alcohol, insoluble in
n-propanol. |
Complies |
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Identification |
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IR |
Should comply |
Complies |
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HPLC |
Should comply |
Complies |
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Bromide |
Should comply |
Complies |
|
Tests |
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Loss of drying |
≤1.0% |
0.22% |
|
Sulphated ash |
≤1.0% |
0.11% |
|
Heavy metal |
≤20ppm |
2.2 |
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Assay |
99% |
99.5% |
Biological effects:
Galanthamine extract is specific, competitive and reversible acetylcholinesterase inhibitor. It is also an allosteric modulator at nicotinic cholinergic receptor sites potentiating cholinergic nicotinic neurotransmission. Both the acetylcholine and nicotine receptors have been suggested as areas related to cognitive impairment. Initially, Galanthamine extract was used in anesthesiology to antagonize the effects of non-depolarizing muscle relaxants, and since then it was rapidly introduced in other areas of medicine, i.e. neurology, ophthalmology, gastroenterology, intensive care and resuscitation, cardiology, physiotherapy.
Galanthamine extract is a product with broad therapeutic index, allowing "soft" manifestation of its effect with individual dosing depending on the particular case.
Several trials already showed that Galantamine 16 and 24 mg/day significantly benefits the cognitive, functional, and behavioral symptoms of AD as compared with placebo and proved also to be very effective in symptomatic treatment of senile dementia of Alzheimer's type
China (Mainland)