High Quality Best Price of Temozolomide CAS 85622-93-1 Anti-cancers Powder
Temozolomide: 4-Methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide
Molecular Structure:
Molecular Formula: C6H6N6O2
Molecular Weight: 194.15
CAS No.: 85622-93-1
Uses: Antitumor Drug
Purity: >99%
Temozolomide is a chemotherapy drug used to treat certain types of brain tumours called glioblastoma multiforme or anaplastic astrocytoma.
COA
|
Test items |
Requirements |
Results |
|
Description |
A White or off-white crystalline powder; odorless; tasted bitter. |
Complies |
|
Solubility |
Slightly soluble in water, very slightly soluble in dehydrated alcohol, soluble in DMF and very soluble DMSO. |
Complies |
|
Identification |
|
|
A. IR |
A: Conform to reference standard |
Conforms |
|
B. Chemical Property |
B: Dissolve 0.1g the sample with 10ml water, add 5ml dinitro-phenyl-hydrazine, should have marron precipitate. |
Positive |
|
C. HPLC |
C: The retention time of the major peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation |
Conforms |
|
Loss on drying |
≤ 1.0%. |
0.21% |
|
Residue on ignition |
≤ 0.1%. |
0.07% |
|
Heavy metals |
≤ 0.002%. |
Complies |
|
Chloride |
≤ 0.002%. |
Complies |
Impurities by HPLC
Any impurity(Max)
Total impurities |
≤ 0.1%.
≤ 0.3%. |
0.042%
0.08% |
Residual solvents
Ethyl acetate
Alcohol
DMSO |
≤ 0.5%.
≤ 0.5%.
≤ 0.5%. |
Complies
Complies
Complies |
|
Assay (HPLC) |
98.5%~102.0% |
99.80% |
Temozolomide Description
Temozolomide is an antitumor, antiangiogenic compound that has been shown to work by alkylating DNA, typically through addition of a methyl group to guanine in genomic DNA. The efficacy of this compound is dependent on its ability to methylate the DNA, thus triggering apoptosis;
however, some cells are able to repair this damage via the enzymes O-6-methylguanine-DNA methyltransferase (MGMT). As a consequence, temozolomide is far more efficacious in tumor cells that have silenced this repair enzyme. Research has also been conducted to determine whether MGMT inhibitors such as O-6-benzylguanine might help to increase the efficacy of temozolomide. Furthermore, temozolomide has been implicated in causing arrest at the G2/M cell cycle checkpoint, which mightalso play a role in its cytotoxicity.
We accept payments throught Telex transfer, Paypal, , Escrow, Letter of Credit...
2) Shipping methods
We offer several delivery services to suit all customer needs, such as AIR freight, DHL, FEDEX, TNT, UPS, EMS, SEA freight and others.
3) Delivery
Usually " in stock" orders can be dispatched within 3 working days. If ordered items are out of stock within 10 days and can't be dispatched in 3 days, we will advise you ASAP, you can change the order or cancel the order ( full amount will be refund)
High quality, best price, first-class service, high successful delivery rate, we have stock, so we can delivery quickly at the very day when payment is arrived.
China (Mainland)