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Details
Chemical Information:
Quick Details:
Product Name: Fidaxomicin
Other Names: FidaxoMicin;3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-b-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-b-D-lyxo-hexopyranosyl)oxy]-11(S)-ethyl-8(S)-hydroxy-18(S)-(1(R)-hydroxyethyl)-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaene-2-one;OPT-80;PAR-101;R-Tiacumicin B;FidaxoMicin(LipiarMycin);ClostoMicin B1, LipiarMycin A3, TiacuMicin B, OPT 80;Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-, (3E,5E,8S,9E,11S,12R,13E,15E,18S)-
Model No.: SYT-759
CAS No.: 873857-62-6
Molecular Formula: 52H74Cl2O18
Molecular Weight: N/A
Appearance: White or Nearly White Crystalline Powder
Melting Point: N/A
Purity: 99.6%
COA: Available
MSDS: Available
Spectrum: Available
Suitable People: ALL People
Product Specifications: Pharmaceutical Grade
Standard: Qualified
MOQ(Minimum Order Quantity): 100g
Payment Term:T/T, , MoneyGram
Shipment: EMS, DHL, FedEx, TNT
Delivery: Within 24hours After Your Payment
Packing: Aluminum Foil Bags or Fiber Drum
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Product Description:
Fidaxomicin(trade names Dificid, Dificlir, and previously OPT-80 and PAR-101) is the first in a new class of narrow spectrum macrocyclic antibiotic drugs. It is a fermentation product obtained from the actinomycete Dactylosporangium aurantiacum subspecies hamdenesis. Fidaxomicin is non-systemic, meaning it is minimally absorbed into the bloodstream, it is bactericidal, and it has demonstrated selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora. The maintenance of normal physiological conditions in the colon can reduce the probability of Clostridium difficile infection recurrence.
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Applications:
It is marketed by Cubist Pharmaceuticals after acquisition of its originating company Optimer Pharmaceuticals. The target use is for treatment of Clostridium difficile infection.
Fidaxomicin belongs to a group of macrocyclic antibiotic drugs. These particular pharmaceutical drugs have a molecular structure comprised of a large macrolide ring to which one or more sugars attach. Laboratories formulate fidaxomicin by fermenting bacteria known as Dactylosporangium aurantiacum. The tablets are coated with an enteric layer, which ensures that the medication only activates after traveling to the bowel.
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Usage:
Physicians may prescribe fidaxomicin for the treatment of Clostridium difficile and associated diarrhea. The oral anti-infective product specifically targets the Clostridium organism. Reports indicate that fidaxomicin causes fewer of the gastrointestinal side effects commonly associated with antibiotics. Studies also suggest that fewer patients undergoing treatment with the medication experience resurgence of bacterial colonization.
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Dosage:
Fidaxomicin is available in a 200 mg tablet that is administered every 12 hours for a recommended duration of 10 days. Total duration of therapy should be determined by the patient's clinical status. It is currently one of the most expensive antibiotics approved for use. A standard course costs upwards of £1350.
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Notes:
Typical side effects associated with the anti-infective include abdominal pain with possible nausea and vomiting. In rare instances, patients may suffer gastrointestinal bleeding. Some patients may experience anemia with a particular decrease in the number of neutrophils, white blood cells that are part of the immune system that fights infection.
China (Mainland)