Pharmaceutical Raw Powders Imiquimod CAS 99011-02-6 For Treating genital wart
Basic Information:
Product name:Imiquimod
MP 292-294°C
Synonyms:R-837;S-26308;ALDARA;IMIQUIMOD
storage temp. Store at +4°C
Appearance :White to off white crystalline powder
Stability: Incompatible with strong oxidizing agents.
CAS: 99011-02-6
MF : C14H16N4
MW: 240.3
Purity: 99%
Grade: USP standard
Imiquimod Description:
Imiquimod works by stimulating the immune system to release a number of chemicals called cytokines, which are important in fighting viruses and destroying cancer cells.
When used to treat skin cancers and pre-cancerous lesions it results in inflammation, which destroys the lesion. The degree of inflammation is quite variable from person to person, in part due to the type of skin lesion and in part due to genetic factors. The imiquimod is taken up by the so-called 'toll-like receptor 7' on certain immune cells that are found in the outside part of the skin (the epidermis); these receptors are expressed more in some individuals and in some skin lesions than in others.
Imiquimod is a prescription medication that acts as an immune response modifier and is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis. Scientists at 3M's pharmaceuticals division discovered the drug and 3M obtained the first FDA approval in 1997 under the brand Aldara. As of 2015 imiquimod is generic and is available worldwide under many brands.
Imiquimod is a patient-applied cream prescribed to treat genital warts and, secondary to surgery, for basal cell carcinoma, as well as actinic keratosis.
Imiquimod COA :
|
Items |
Specification |
Results |
|
Appearance |
White Powder |
Conform |
|
Allantoin content (C4H6N4O3) |
99.00%min |
Conform |
|
pH Value (0.5%w.s.) |
3.5-6.5 |
Conform |
|
Loss on Dry |
0.20% max |
Conform |
|
Sulphate |
0.02% max |
Conform |
|
Heavy Metal (Based on Pb) |
0.001% max |
Conform |
|
Glycoluril |
0.2% max |
Conform |
|
Melting Point |
Around 230
Decompose |
Conform |
|
Conclusion |
Conforms Specifications of Enterprise Standard. |
Imiquimod Application:
It can be used for the treatment of adult external genital and perianal genital warts at 3 times per week. Just before sleep, first apply the product evenly in a thin layer on the surface of the wart and gently massage until the product is completely absorbed.
The position of the medication should not be packeted and should be maintained for 6 to 10 hours, and then wash with a neutral soap and clean water for clearing the drugs in the administration site. Wash your hands before and after treatment.
250 mg of cream can be applied to 20cm2 of wart. Avoid excessive application of the drug. Patients should continue the treatment until the wart is completely cleared. Wart can be cleared within 2-4 week at the fastest speed and can be generally cleared within 8 to 12 weeks. The medication should be not more than 16 weeks.
After the treatment, patients with mild erythema locally who does not have to be discontinued for drug; if the patients feel general malaise or get local skin reactions (edema, erosion, pain, etc.), the drug should be discontinued. Only when the reaction is alleviated can they continue the medication.
China (Mainland)